* Simple definition: "Water is a pure substance made up of hydrogen and oxygen."
* Contrast with mixtures: "Salt is a pure substance, while seawater is a mixture of salt and water."
* Emphasis on purity: "The scientist carefully analyzed the pure substance to ensure its composition was correct."
* Describing a process: "The purification process removed impurities to produce a pure substance."
* In a more technical context: "The pure substance was analyzed using chromatography to identify its components."
The key is to use "pure substance" to describe something that is made up of only one type of molecule or atom.