Common words:
* Careless: Without care.
* Hopeless: Without hope.
* Homeless: Without a home.
* Jobless: Without a job.
* Pointless: Without a point.
* Powerless: Without power.
* Sleepless: Without sleep.
* Thoughtless: Without thought.
* Worthless: Without worth.
Less common words:
* Aimless: Without aim or purpose.
* Boundless: Without bounds or limits.
* Clueless: Without clues or information.
* Fearless: Without fear.
* Friendless: Without friends.
* Heartless: Without compassion or empathy.
* Meaningless: Without meaning or significance.
* Nameless: Without a name.
* Shameless: Without shame or remorse.
* Skillless: Without skills or ability.
* Speechless: Without words.
* Tasteless: Without flavor.
* Timeless: Without time or age.
* Useless: Without use or purpose.
Words with variations:
* Childless
* Countless
* Effortless
* Faultless
* Fearless
* Flawless
* Hairless
* Helpless
* Leaderless
* Meaningless
* Merciless
* Nameless
* Numberless
* Penetrable
* Powerless
* Ruthless
* Seedless
* Shameless
* Soundless
* Speechless
* Thoughtless
* Traceless
* Valueless
* Waterless
* Worthless
The suffix "-less" generally indicates the absence of something or the lack of a quality.