Here's a breakdown:
* If "fortunately" introduces a dependent clause: Yes, you use a comma.
* Example: "Fortunately, I had an umbrella, so I didn't get wet."
* If "fortunately" is used as an interjection: Yes, you use a comma.
* Example: "Fortunately, the storm passed quickly."
* If "fortunately" modifies a noun or pronoun: No comma needed.
* Example: "We had a fortunately uneventful journey."
In general, if "fortunately" introduces a new thought or idea, use a comma. If it's directly modifying a word, you don't need one.