* im-: to express the opposite of probable, meaning "improbable".
* un-: similar to "im-", also meaning "improbable".
* highly-: to emphasize a high degree of probability.
* most-: similar to "highly-", expressing a very high level of probability.
* in-: sometimes used to indicate the opposite of a word, so could be used for "improbable".
The specific prefix you choose will depend on the context and the nuance you want to express.