Here are some possibilities and their translations depending on what you mean:
* "Cómo desis" (How do you give up?) - This would be asking someone how they manage to give up on something.
* "Cómo desis de" (How do you give up on...) - This would be asking someone how they give up on something specific, like a project, a habit, etc.
* "Como desis tu" (How do you give up yourself?) - This would be asking someone how they give up on themselves or their own dreams.
To help me understand better, please provide the full phrase or context of what you are trying to translate.