Simple:
* The teacher instructed the students to open their books to page 25.
* The doctor instructed the patient on how to take their medication.
With different parts of speech:
* The manual instructs users on how to assemble the furniture. (verb)
* The instructions were clear and easy to follow. (noun)
* The instructor showed us how to perform the experiment. (noun)
* She received instructive feedback on her presentation. (adjective)
In different contexts:
* The general instructed his troops to advance. (military)
* The computer program instructs the robot on how to move. (technology)
* The judge instructed the jury to consider all the evidence. (law)
* The coach instructed the team on how to improve their strategy. (sports)
You can see that "instruct" is a versatile word that can be used in many different ways.