General prefixes for negation:
* Un- : Unlikely, uncharacteristic
* Dis- : Dissimilar, disinclined
* In- : Incomparable, incompatible
* Non- : Nonconformist, nonpartisan
Specific prefixes for similarity/likeness:
* A- : Atypical, asymmetrical (meaning "not typical" or "not symmetrical")
* Anti- : Antithetical, antithesis (meaning "opposite" or "against")
Examples:
* Unlike (already negates "like")
* Not similar (uses the negation "not" before "similar")
The best prefix to use depends on the specific context and the word you're trying to modify.