When "thus" is used as a conjunction:
* Yes, use a comma: When "thus" introduces a dependent clause, a comma is needed.
* Example: "It was raining heavily, thus making it difficult to drive."
When "thus" is used as an adverb:
* No, no comma needed: When "thus" modifies a verb or clause, it doesn't need a comma.
* Example: "The team played well and thus won the championship."
To be sure, consider the sentence structure and the meaning of "thus" in your specific case.