For "know someone/something":
* Connaître: This is the most common way to say "know" someone or something.
* "Je connais un homme." (I know a man.)
* "Connaissez-vous Paris?" (Do you know Paris?)
For "to know how to":
* Savoir: This translates to "to know how to" or "to know that."
* "Je sais parler français." (I know how to speak French.)
* "Je sais qu'il est parti." (I know that he left.)
For "to be familiar with":
* Connaître: This can also be used for being familiar with something, but sometimes "être familier avec" is more precise.
* "Je connais bien cette ville." (I know this city well.)
* "Je suis familier avec ce sujet." (I am familiar with this topic.)
The best translation will depend on the specific context and what you are trying to express.