Here are some examples:
With a comma:
* As a matter of fact, the meeting was canceled.
* As the sun began to set, the sky turned a brilliant orange.
* As you may know, I'm moving to a new city next month.
Without a comma:
* As soon as I get home, I'm going to bed.
* As long as you're happy, I'm happy.
Note: If "as" introduces a dependent clause (a clause that cannot stand alone as a sentence), a comma is always required.
Example:
* As I was walking down the street, I saw a dog chasing a squirrel.
Exceptions:
* Sometimes, even if the phrase is longer than four words, a comma is not necessary if the phrase is closely connected to the main clause and doesn't create ambiguity.
* If "as" introduces a direct address or a parenthetical element, you do not need a comma.
Examples:
* As you know, this is a very important project. (direct address)
* As a matter of fact, I think this is a good idea. (parenthetical)
Ultimately, the best way to decide whether to use a comma is to read the sentence aloud and listen for natural pauses. If you pause after the phrase, it's likely that a comma is needed.