Is the word clothes a prefix or suffix?

"Clothes" is neither a prefix nor a suffix. It's a noun that refers to items of clothing.

Here's why:

* Prefixes are word parts added to the beginning of a word to change its meaning (e.g., "un-" in "unhappy").

* Suffixes are word parts added to the end of a word to change its meaning (e.g., "-ing" in "walking").

"Clothes" stands on its own as a complete word.