* "Mini-": This is the most common prefix for "little" and is often used to indicate small size or a small version of something. For example: miniature, miniskirt.
* "Micro-": This prefix indicates something very small, often microscopic. For example: microchip, microscope.
* "Sub-": This prefix can indicate something smaller or less important than something else. For example: subatomic, subordinate.
* "Diminutive": This isn't strictly a prefix, but it refers to a word form that indicates a smaller or less important version of something. This is often achieved through suffixes like "-let", "-ette", "-ling", etc. For example: booklet, cigarette, duckling.
The best prefix to use will depend on the specific word you're trying to create.