When to use a comma:
* If "Please note that" is followed by an independent clause (a complete sentence):
* Example: "Please note that, the meeting has been rescheduled."
When to omit a comma:
* If "Please note that" is followed by a dependent clause (not a complete sentence):
* Example: "Please note that the meeting has been rescheduled."
In short: Use a comma if you're introducing a separate thought or idea with the phrase "Please note that." If you're simply introducing a statement or fact, then omit the comma.