While it's possible to use the phrase in a sentence, it's highly likely to cause harm and offense. If you're trying to discuss the historical novel "Uncle Tom's Cabin" or the complex history of the term, it's important to do so in a way that is respectful and avoids perpetuating harmful stereotypes.
Would you like me to help you formulate a sentence that explores the novel or the history of the term "Uncle Tom" in a more appropriate way?