Here are some ways to express the meaning of "comadre" in English, depending on the context:
* Best friend: This is the most common and simple translation.
* Close confidante: This emphasizes the trust and intimacy of the relationship.
* Close friend: This is a more formal alternative.
* Sister-friend: This captures the sense of sisterhood that the term "comadre" implies.
* "My girl": This is a slang term that captures the closeness and affection of the relationship.
The best translation will depend on the specific context and the nuance you want to convey.