General:
* Novel: This is a common word that simply means new and original.
* Unprecedented: This word implies that something has never happened before.
* Unparalleled: This word emphasizes that something is unique and unmatched.
More specific:
* Pioneering: This word suggests that something is groundbreaking and innovative.
* Revolutionary: This word implies that something is a radical departure from the old ways of doing things.
* Avant-garde: This word refers to something that is at the forefront of new developments, often in art or culture.
* Uncharted: This word suggests that something is unexplored and unknown.
The best word to use will depend on the context of your sentence.