Using a semicolon and a conjunction:
* You ate the ketchup; she drank motor oil, and it was a disaster.
Using a semicolon and a conjunctive adverb:
* You ate the ketchup; she drank motor oil; consequently, it was a disaster.
Using a comma and a coordinating conjunction:
* You ate the ketchup, and she drank motor oil, so it was a disaster.
Using a colon:
* It was a disaster: you ate the ketchup, and she drank motor oil.
Using a dash:
* You ate the ketchup – she drank motor oil – it was a disaster.
The best option depends on the desired emphasis and flow of your writing.