* Business: "The company buys its merchandise wholesale from a distributor, which allows them to sell it at a lower price."
* General: "After the storm, the supermarket was selling bread wholesale to prevent shortages."
* Figurative: "The new marketing campaign was a wholesale change from their previous strategy."
* With a negative connotation: "The company's CEO made wholesale cuts to the staff, leaving many employees unemployed."
These are just a few examples. The specific context will determine the best way to use "wholesale" in a sentence.