* Period (.) If "nope" is the end of a sentence, use a period.
* Example: "Are you coming to the party? Nope."
* Question mark (?) If "nope" is a response to a question, use a question mark.
* Example: "Did you finish your homework? Nope."
* Exclamation mark (!) If "nope" is used to express strong emotion, use an exclamation mark.
* Example: "Are you serious? Nope!"
* Comma (,) If "nope" is part of a longer sentence, use a comma.
* Example: "I was thinking about going to the movies, but nope, I'm too tired."
Ultimately, choose the punctuation that best reflects the intended meaning and tone of your sentence.