If you're asking a question:
* Are you leaving early today? (Most common and natural)
* Will you be leaving early today? (If you're asking about a future event)
* Do you plan on leaving early today? (If you're asking about their intention)
If you're making a statement:
* You are leaving early today.
* You're leaving early today. (Informal)
If you're expressing surprise or concern:
* You're leaving early today? (This implies surprise, with a slight rising inflection)
* Are you sure you have to leave early today? (This implies concern)
The best choice depends on the context and your intended meaning.