If you meant "screw," here's the definition:
Screw: A type of fastener, typically made of metal, with a helical ridge, called a thread, wrapped around a cylindrical or conical shaft. Screws are used to join objects together by engaging their threads with mating threads in a nut or in a tapped hole.
Other possibilities:
* If you meant "askew," it means not straight or level; crooked.
* If you meant "a screw-up," it refers to a mistake or a blunder.
Please provide more context so I can help you understand what you're looking for.