Formal:
* La vie est nulle. (This is the most literal translation, meaning "Life is null.")
* La vie est sans intérêt. (Meaning "Life is without interest.")
* La vie est décevante. (Meaning "Life is disappointing.")
Informal:
* La vie, c'est de la merde. (This is very vulgar and means "Life is shit.")
* La vie, c'est pourri. (Meaning "Life is rotten.")
* La vie, c'est un vrai bordel. (Meaning "Life is a real mess.")
More nuanced:
* Je suis blasé de la vie. (Meaning "I'm jaded with life.")
* J'en ai marre de la vie. (Meaning "I'm sick of life.")
* La vie ne vaut pas la peine. (Meaning "Life isn't worth it.")
The best option for you will depend on the context and your relationship with the person you are speaking to.