Simple:
* I comprehend the instructions now.
* It took me a while to comprehend the complex math problem.
* She could not comprehend the depth of his grief.
More complex:
* The students struggled to comprehend the abstract concepts of quantum physics.
* Despite the language barrier, they were able to comprehend each other's emotions.
* The author uses vivid imagery to help readers comprehend the character's inner turmoil.
In a figurative sense:
* Her words were so profound, I could barely comprehend their meaning.
* The vastness of the universe is impossible to comprehend.
Remember that "comprehend" means to understand fully, so choose your sentence to reflect that meaning.