* in-: Prefix meaning "not"
* -de-: Prefix meaning "undo" or "remove"
* -fatigable: This part comes from the word "fatigable," meaning "capable of being tired."
Therefore, the word "indefatigable" has three prefixes/suffixes:
* in-
* -de-
* -able (though it's technically part of the root word "fatigable")