General:
* Un-: This prefix implies a lack of something, making it a good option for "inept" (e.g., "unskilled").
* In-: This prefix also signifies a lack of something, often used in words relating to ability (e.g., "incapable").
* Non-: This prefix indicates the absence of something, similar to "un-" and "in-" (e.g., "non-talented").
Specific:
* Mal-: This prefix suggests something bad or wrong, implying a lack of skill or ability (e.g., "maladroit").
* Mis-: This prefix indicates a mistake or error, suggesting ineptness in execution (e.g., "misguided").
* Dys-: This prefix relates to difficulty or impairment, highlighting a lack of skill or ability (e.g., "dysfunctional").
The best prefix will depend on the context and the specific meaning you want to convey.