General synonyms:
* Miserable
* Wretched
* Despicable
* Deplorable
* Pitiful
* Degraded
* Humiliating
* Lowly
* Base
Synonyms emphasizing despair or hopelessness:
* Hopeless
* Desperate
* Dejected
* Disheartened
Synonyms emphasizing degradation or humiliation:
* Shameful
* Disgraceful
* Ignominious
* Demeaning
* Servile
The best synonym will depend on the context of your sentence and the specific emotion you want to evoke.