Direct opposites:
* Misunderstanding: This is the most straightforward opposite, meaning to interpret something incorrectly.
* Ignorance: This refers to a lack of knowledge or awareness, making comprehension impossible.
* Confusion: This is a state of being bewildered or disoriented, making it difficult to grasp meaning.
* Disbelief: This is a rejection of something as being true, preventing understanding.
Other antonyms depending on context:
* Disregard: This refers to ignoring or paying no attention to something, which prevents understanding.
* Opposition: This indicates active resistance or disagreement with a concept, making it difficult to see its merits.
* Blindness: This can be metaphorical, referring to a lack of insight or awareness that prevents understanding.
Ultimately, the best opposite of understanding depends on the specific situation and what is being understood.