* Disadvantageous: This is the most direct opposite, meaning unfavorable or harmful.
* Detrimental: This implies something that causes harm or damage.
* Unfavorable: This is a general term for something that is not beneficial.
* Harmful: This refers to something that causes damage or injury.
* Unprofitable: This refers to something that does not generate a profit.
* Unbeneficial: This is a more formal way of saying "not beneficial."
The best antonym will depend on the specific situation and the intended meaning.