Formal:
* In conclusion
* To summarize
* Overall
* In general
* Ultimately
* In the end
Informal:
* Basically
* In short
* Long story short
* On the whole
* All things considered
* At the end of the day
More specific alternatives:
* Taking everything into account...
* Considering all factors...
* Weighing all the pros and cons...
* From this perspective...
* Looking at the bigger picture...
The best choice will depend on the context and tone of your writing or speech.