General fussiness:
* Commotion
* Stir
* Uproar
* Disorder
* Confusion
* Agitation
Unnecessary concern:
* Concern
* Worries
* Troubles
* Anxiety
Exaggerated attention:
* Hullabaloo
* Fanfare
* Fluster
* To-do
Over-elaborate presentation:
* Frills
* Trimmings
* Embellishments
Unnecessary attention to detail:
* Nitpicking
* Quibbling
* Pickiness
* Fretting
Complaining or arguing:
* Whining
* Grumbling
* Nagging
* Bickering
For example, if you're talking about a child making a fuss, you might use "commotion," "stir," or "agitation." If you're talking about someone making a fuss over a small issue, you might use "worry," "trouble," or "fuss."
To choose the best synonym, consider the specific situation and the intended meaning.