General:
* Skill
* Proficiency
* Mastery
* Competence
* Know-how
* Specialization
* Talent
* Ability
More Formal:
* Acumen
* Savvy
* Craftsmanship
* Eminence
* Authority
Informal:
* Knack
* Gift
* Talent
* Know-how
For specific areas:
* Technical expertise (for technical skills)
* Clinical expertise (for medical skills)
* Financial expertise (for financial skills)
The best synonym will depend on the specific context and the level of formality desired.