What is a synonym for comprehensive grasp?

Here are some synonyms for "comprehensive grasp," depending on the specific nuance you want to convey:

General:

* Full understanding

* Thorough knowledge

* Deep comprehension

* Complete mastery

* Wide-ranging understanding

* Complete grasp

* Solid understanding

Formal:

* Encompassing knowledge

* Exhaustive understanding

* Total comprehension

* Broad purview

Informal:

* Knowing the ropes

* Having a good handle on

* Figuring it out

* Getting the picture

The best synonym depends on the context of your writing and the specific meaning you want to convey.