* Illness: This is the most general and common abstract noun for being sick.
* Sickness: Similar to "illness," but often implying a more severe or prolonged state.
* Ailment: Refers to a specific illness or health problem.
* Malaise: A general feeling of discomfort, uneasiness, or illness.
* Disease: A specific condition with identifiable symptoms and causes.
* Infection: A state of being infected by a pathogen.
* Debilitation: A state of weakness and loss of strength.
The best choice will depend on the specific context of your writing.