General synonyms:
* Disaster
* Catastrophe
* Misfortune
* Tragedy
* Hardship
* Affliction
* Adversity
More specific synonyms:
* For a sudden, destructive event: Devastation, upheaval, havoc, ruin, wreck
* For a personal misfortune: Misery, woe, grief, sorrow, heartbreak
* For a societal or widespread disaster: Plague, scourge, epidemic, famine, war
The best synonym for "calamity" will depend on the context and the specific meaning you want to convey.