General antonyms:
* Condemn: To express strong disapproval of someone or something.
* Criticize: To find fault with someone or something.
* Incriminate: To accuse someone of a crime.
* Convict: To find someone guilty of a crime.
* Blame: To hold someone responsible for something bad.
* Defame: To damage someone's reputation by spreading false information.
* Disgrace: To bring shame or dishonor upon someone.
Antonyms specific to legal contexts:
* Acquit: To find someone not guilty of a crime.
* Dismiss: To reject a claim or accusation.
Antonyms specific to personal situations:
* Humiliate: To make someone feel ashamed or embarrassed.
* Degrade: To lower someone's status or dignity.
* Discredit: To damage someone's credibility or reputation.
Ultimately, the best antonym for "vindicate" will depend on the specific context of the situation.