Here's a breakdown:
* Despite: This is the most common synonym for "in spite of." It emphasizes the contrast between the obstacle and the outcome.
* Regardless of: This emphasizes that something is happening without being affected by a particular factor.
* Even though: This explicitly acknowledges the obstacle but indicates that it doesn't prevent the outcome.
Examples:
* In spite of the rain, we went for a walk. (Despite the rain, we still went for a walk.)
* In spite of her illness, she went to work. (Even though she was ill, she still went to work.)
* In spite of the fact that he was tired, he finished the project. (Regardless of his tiredness, he finished the project.)
Note: "In spite of" is often used interchangeably with "despite" in most contexts. However, "in spite of" can sometimes sound more formal or literary.