General Opposites:
* Condemn: To declare to be wrong or guilty.
* Criticize: To find fault with.
* Disprove: To show something to be false.
* Refute: To prove something to be wrong.
* Accuse: To charge someone with a crime or wrongdoing.
* Incriminate: To show evidence of someone's guilt.
* Blame: To hold someone responsible for something bad.
* Convict: To find someone guilty of a crime.
Specific Opposites Related to Reputation:
* Defame: To damage someone's reputation.
* Slander: To make false and damaging statements about someone.
* Disgrace: To bring shame or dishonor upon someone.
* Humiliate: To cause someone to feel ashamed or embarrassed.
Other Opposites:
* Suppress: To prevent something from being expressed or known.
* Conceal: To hide something.
* Deny: To refuse to acknowledge something.
* Discredit: To damage someone's credibility.
The best opposite word will depend on the specific context in which "vindicate" is used.