* If "let" means "allow" or "permit", its antonym could be "forbid", "prohibit", "prevent", or "stop".
* If "let" means "release" or "free", its antonym could be "hold", "retain", or "capture".
* If "let" is used in the phrase "let go", its antonym could be "hold on".
* If "let" means "say", its antonym could be "keep silent".
To give you the most precise antonym, please provide me with the sentence where "let" is used.