Formal:
* શું કોઈ સમસ્યા છે? (Shu koi samasya chhe?) - This is the most direct and literal translation.
* શું કોઈ મુશ્કેલી છે? (Shu koi mushkeli chhe?) - This is a slightly more formal and polite way to ask.
Informal:
* કોઈ તકલીફ છે? (Koi taklif chhe?) - This is a casual way to ask.
* કોઈ પ્રોબ્લેમ છે? (Koi problem chhe?) - This is a more informal way to ask and uses the English word "problem."
For a specific issue:
* શું આમાં કોઈ સમસ્યા છે? (Shu aama koi samasya chhe?) - This translates to "Is there any problem with this?"
* શું તમને કોઈ સમસ્યા છે? (Shu tame ne koi samasya chhe?) - This translates to "Are you having any problems?"
The best way to choose the right phrase depends on the situation and your relationship with the person you are speaking to.