General synonyms:
* Worsen: This is a very close synonym and is often used when talking about making a situation or condition worse.
* Exacerbate: This implies making something more severe or intense.
* Irritate: This refers to causing annoyance or displeasure.
* Annoy: Similar to irritate, but often less intense.
* Provoke: This implies deliberately causing a reaction, often negative.
* Infuriate: This means to make someone extremely angry.
Synonyms specific to injuries or illnesses:
* Inflame: This refers to making something swollen and painful.
* Exasperate: This implies making something more painful or difficult to bear.
Synonyms related to emotions:
* Upset: This implies making someone unhappy or distressed.
* Frustrate: This refers to making someone feel discouraged or unable to achieve something.
* Displease: This implies causing dissatisfaction or displeasure.
Informal synonyms:
* Bug: This is a slang term for annoy.
* Piss off: This is a more vulgar way of saying "annoy" or "irritate."
The best synonym for "aggravate" will depend on the specific context and the desired level of formality.