* spire: a tall, pointed structure (e.g., a church spire)
* spirit: a person's non-physical part, soul or vital principle (e.g., team spirit)
* aspire: to have a strong desire for something (e.g., to aspire to greatness)
* inspire: to fill someone with the urge or ability to do or feel something (e.g., to inspire confidence)
The root word "spir" comes from the Latin word "spirare," meaning "to breathe."
If you have another word in mind that contains "spir," please provide it, and I can help you understand its origin and meaning.