General:
* Bitterness
* Harshness
* Sharpness
* Asperity
* Rancor
* Acridness
* Venom
More intense:
* Spite
* Malice
* Hatred
* Hostility
More specific:
* For a relationship: Estranged, Antagonistic, Fractious
* For language: Caustic, Scathing, Cutting, Vitriolic
The best synonym will depend on the specific context in which you are using the word.