If "poultice" refers to the application of a soothing substance:
* Exacerbation: To make a condition worse, the opposite of soothing.
* Stimulation: To provoke a reaction, rather than calm or soothe.
* Excision: To remove tissue, the opposite of applying something.
* Surgery: A more invasive medical procedure that contrasts with the simple application of a poultice.
If "poultice" refers to the substance itself:
* Antiseptic: A substance that kills germs, while a poultice may not have that property.
* Anti-inflammatory: A medication that reduces swelling, while some poultices might not.
* Medication: A more general term for a substance used for medical treatment.
Ultimately, the best antonym depends on the specific context and what aspect of "poultice" you want to contrast.