Here are some examples of how it might be used:
* "How are you feeling today?" "I'm feeling much better, thanks. I'm up and about."
* "It was a long night, but I'm up and about and ready for the day."
* "The doctor said I should be up and about in a few days."
It can also be used in a more general sense to mean busy or active in a particular place or situation.
* "The city was up and about with people celebrating the festival."
* "The newsroom was up and about all night covering the election results."
The expression is often used in a positive sense, implying a sense of wellbeing or energy.