Here's how you can use it in a sentence:
* As an adjective: "She is up for the challenge of climbing Mount Everest."
* As an adverb: "He accepted the job, knowing he was up for the challenge."
You can also use it as a standalone phrase in certain contexts, especially when it's implied that someone is ready for a challenge:
* "Are you up for the challenge?"
In this case, it's understood that the speaker is asking if the listener is willing to take on a specific task.