If you're thinking about the *absence* of instruments:
* With instruments: This directly contrasts the lack of instruments in a cappella.
* Instrumental: This emphasizes the presence of instruments, as opposed to only voices.
If you're thinking about the *presence* of instruments:
* Unaccompanied: This highlights the absence of instruments, just like "a cappella".
* Vocal only: This clearly states that the music is solely made with voices.
If you're thinking about the *musical style*:
* Orchestral: This refers to a larger ensemble that includes instruments.
* Instrumental music: This refers to any music that doesn't use voices.
Ultimately, the best opposite for "a cappella" depends on the context and what you're trying to convey.