"Apples to oranges" means comparing things that are completely different and not comparable. It suggests that the comparison is pointless or misleading because the items are fundamentally dissimilar.
Here are some examples of how it's used:
* "Comparing the two books is like comparing apples to oranges. They are written for completely different audiences."
* "You can't say one career path is better than another; it's like comparing apples to oranges."