It's a common and versatile word, used in many contexts, including:
* Informal: "Hey, hombre, what's up?"
* Formal: "El hombre es el arquitecto de su propio destino." (The man is the architect of his own destiny.)
* In literature and music: often used in a more poetic sense, like "El hombre de la Mancha" (the man from La Mancha).
Note: "Hombre" is the masculine form. The feminine form is "mujer".