Here are some possible interpretations of your question and the words that might fit:
* Most letters: The word "pneumonoultramicroscopicsilicovolcanoconiosis" has 45 letters, making it the longest word in the English language.
* Most syllables: "pneumonoultramicroscopicsilicovolcanoconiosis" also has 15 syllables, making it the word with the most syllables.
* Most meanings: The word "set" has hundreds of meanings, making it one of the most polysemous words in English.
* Most difficult to pronounce: While "pneumonoultramicroscopicsilicovolcanoconiosis" is long, words like "floccinaucinihilipilification" are considered more difficult to pronounce for native speakers.
* Most frequently used: Words like "the", "a", and "be" are used extremely frequently in English, though it's hard to say definitively which one is the "most" used.
Ultimately, the answer depends on how you define "most".