Formal:
* Acerbic: This word implies a sharp, biting, and often sarcastic tone.
* Caustic: This word suggests a burning, corrosive, and deeply critical nature.
* Sardonic: This word refers to a mocking and cynical tone, often tinged with bitterness.
Informal:
* Biting: This word is a more general term for speech that is sharp and critical.
* Scathing: This word implies a severe and withering criticism.
* Snarky: This word refers to a sarcastic and often mean-spirited tone.
* Sour: This word suggests a general negativity and pessimism in speech.
The best word to use will depend on the specific context and the intensity of the bitterness you want to convey.